Lipidomic analyses of large cohort studies define the role of lipid metabolism in bridging diet and cardio-metabolic health.

Abstract

Diet is a key factor for many diseases, yet the underlying metabolic pathways involved remain poorly understood. We analyze data from 13,335 participants across two large Australian cohorts examining comprehensive lipidomic profiles in relation to diet. We also assess the link between metabolic signatures of dietary quality with cardiometabolic health and all-cause mortality. Here, using linear models and lipid set enrichment analysis, we report characteristic lipidomic profiles associated with dairy [sphingomyelins and lipids esterified with 14:0, 15:0, 17:0 or 17:1 fatty acid], red meat and poultry [alkyl- and alkenyl-phosphatidylcholine and phosphatidylethanolamine notably, with arachidon..